The Medical Use Of Vanadium

Vanadium is a trace element in the human body, with a content of approximately 25mg. Under pH 4-8 conditions in body fluids, the main form of vanadium is VO3-, which is vanadate ion; The other is the+5 valence oxidation form VO43-, which is the orthovanadate ion. Due to similar biological effects, vanadates generally refer to these two+5 valence oxidation ions. VO3- enters cells through ion transport systems or freely, and is reduced by reduced glutathione to VO2+(+4 oxidation state), which is the vanadyl ion. Due to the widespread presence of phosphate and Mg2+ions in cells, VO-3 and phosphate have similar structures, and VO2+and Mg2+are of similar sizes (ion radii of 160pm and 165pm, respectively). Therefore, they may interfere with the biochemical reaction process of cells by competing with phosphate and Mg2+to bind ligands. For example, inhibiting ATP hydrolase, ribonuclease, phosphofructose kinase, phosphoglyceraldehyde kinase, 6-phosphoglucosidase, and phosphotyrosine protein kinase. So, vanadium has a wide range of biological effects after entering cells. Vanadium compounds have the advantages of relatively easy synthesis and low cost, so studying the depressurization mechanism of vanadium compounds is beneficial for the development and utilization of vanadium.